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A preclinical pilot study in human patients with chronic pain episodes found, that DSIP significantly reduced pain perception, also improved mood by reduction of depressive states, and that it may potentially be of interest for research into physiological addiction on pain medications, as it was observed to reduce withdrawal symptoms that occurs after discontinuation of long-term analgesic treatment

This is also the case for people on long-term proton-pump inhibitor-type treatment

Thioredoxin reductase maintains thioredoxin in its reduced state and thioredoxin is important for immune function and cell survival (45)

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doi: 10.1080/01485010390129269